活体亲属肝移植后可溶性形式的CD95和CD95配体
Soluble forms of CD95 and CD95 ligand after living related liver transplantation.
作者信息
Seino K, Kayagaki N, Yamaguchi N, Takada Y, Uyama S, Kiuchi T, Tanaka K, Yagita H, Okumura K, Fukao K
机构信息
Department of Surgery, University of Tsukuba School of Medicine, Ibaraki, Japan.
出版信息
Transplantation. 1999 Feb 27;67(4):634-6. doi: 10.1097/00007890-199902270-00026.
BACKGROUND
Soluble forms of CD95 and CD95 ligand (sCD95 and sCD95L, respectively) can increase in the serum of patients with some inflammatory disease. In this study, we investigated the serum levels of sCD95 and sCD95L in liver transplantation recipients.
METHODS
Serum levels of sCD95 and sCD95L in living related liver transplant recipients were analyzed by ELISA and their relation to the clinical findings estimated.
RESULTS
Serum samples from the recipients did not show detectable levels of sCD95L but showed significantly increased levels of sCD95. The increase of sCD95 was positively associated with that of total-bilirubin and incidence of rejection, infection, and graft ischemia.
CONCLUSIONS
The present results indicate an existence of sCD95 in the recipients of living related liver transplants. The increased serum levels of sCD95 may modify the immunological situation of the recipients after transplantation or represent the ongoing graft damage.
背景
可溶性形式的CD95和CD95配体（分别为sCD95和sCD95L）在一些炎症性疾病患者的血清中会升高。在本研究中，我们调查了肝移植受者血清中sCD95和sCD95L的水平。
方法
采用酶联免疫吸附测定法（ELISA）分析活体亲属肝移植受者血清中sCD95和sCD95L的水平，并评估其与临床结果的关系。
结果
受者的血清样本未检测到sCD95L水平，但sCD95水平显著升高。sCD95的升高与总胆红素升高以及排斥反应、感染和移植物缺血的发生率呈正相关。
结论
目前的结果表明在活体亲属肝移植受者中存在sCD95。血清中sCD95水平的升高可能会改变移植后受者的免疫状况，或表明正在发生的移植物损伤。
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