急性心绞痛患者血清中可溶性CD95/Fas和半胱天冬酶1/ICE浓度升高。
Increased serum concentrations of soluble CD95/Fas and caspase 1/ICE in patients with acute angina.
作者信息
Ankersmit H J, Weber T, Auer J, Roth G, Brunner M, Kvas E, Moser B, Spreitzer S, Lassnig E, Maurer E, Hartl P, Wolner E, Boltz-Nitulescu G, Eber B
机构信息
Department of Cardiothoracic Surgery, General Hospital of Vienna Medical School, Vienna, Austria.
出版信息
Heart. 2004 Feb;90(2):151-4. doi: 10.1136/hrt.2003.012062.
OBJECTIVES
To investigate the expression of death inducing receptors in the sera of patients with stable and unstable angina.
DESIGN
80 consecutive patients with stable (n = 40) or unstable (n = 40) angina pectoris were studied. Serum concentrations of soluble CD95 (sCD95), soluble CD95 ligand (sCD95L; CD178), tumour necrosis factor (TNF) alpha, soluble TNFalpha receptor type 1 (sTNFR1), and interleukin 1beta converting enzyme (ICE; caspase 1) were measured by enzyme linked immunosorbent assay (ELISA).
RESULTS
Significant increases in the concentrations of sCD95 and ICE (p < 0.001 and p < 0.023, respectively) were found in the serum from patients with unstable angina relative to those with stable angina. There were no significant differences in the concentrations of sCD95L, TNF alpha, and sTNFR1 between the groups.
CONCLUSIONS
These data provide the first evidence that sCD95 and ICE are important serological markers that may help to discriminate between stable and unstable angina. This observation may warrant further clinical study to elucidate the clinical impact of sCD95 and ICE in acute coronary syndromes.
目的
研究稳定型和不稳定型心绞痛患者血清中死亡诱导受体的表达情况。
设计
对80例连续的稳定型（n = 40）或不稳定型（n = 40）心绞痛患者进行研究。采用酶联免疫吸附测定（ELISA）法检测血清中可溶性CD95（sCD95）、可溶性CD95配体（sCD95L；CD178）、肿瘤坏死因子（TNF）α、可溶性TNFα受体1型（sTNFR1）和白细胞介素1β转换酶（ICE；半胱天冬酶1）的浓度。
结果
与稳定型心绞痛患者相比，不稳定型心绞痛患者血清中sCD95和ICE的浓度显著升高（分别为p < 0.001和p < 0.023）。两组之间sCD95L、TNFα和sTNFR1的浓度无显著差异。
结论
这些数据首次证明sCD95和ICE是重要的血清学标志物，可能有助于鉴别稳定型和不稳定型心绞痛。这一观察结果可能需要进一步的临床研究，以阐明sCD95和ICE在急性冠状动脉综合征中的临床影响。
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