Frost J A, Binder J R, Springer J A, Hammeke T A, Bellgowan P S, Rao S M, Cox R W
Department of Neurology, Medical College of Wisconsin, Milwaukee 53226, USA.
Brain. 1999 Feb;122 ( Pt 2):199-208. doi: 10.1093/brain/122.2.199.
Functional MRI (fMRI) was used to examine gender effects on brain activation during a language comprehension task. A large number of subjects (50 women and 50 men) was studied to maximize the statistical power to detect subtle differences between the sexes. To estimate the specificity of findings related to sex differences, parallel analyses were performed on two groups of randomly assigned subjects. Men and women showed very similar, strongly left lateralized activation patterns. Voxel-wise tests for group differences in overall activation patterns demonstrated no significant differences between women and men. In further analyses, group differences were examined by region of interest and by hemisphere. No differences were found between the sexes in lateralization of activity in any region of interest or in intrahemispheric cortical activation patterns. These data argue against substantive differences between men and women in the large-scale neural organization of language processes.
功能磁共振成像（fMRI）被用于研究在语言理解任务中性别对大脑激活的影响。为了最大化检测两性间细微差异的统计功效，研究了大量受试者（50名女性和50名男性）。为了评估与性别差异相关的研究结果的特异性，对两组随机分配的受试者进行了平行分析。男性和女性表现出非常相似的、强烈偏向左侧的激活模式。对总体激活模式进行的体素水平组间差异测试表明，女性和男性之间没有显著差异。在进一步的分析中，通过感兴趣区域和半球来检查组间差异。在任何感兴趣区域的活动偏侧化或半球内皮质激活模式方面，未发现两性之间存在差异。这些数据表明，在语言处理的大规模神经组织方面，男性和女性之间不存在实质性差异。
