Wang J J, Ho S T, Lee S C, Liu Y C
Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Anesth Analg. 1999 Mar;88(3):686-9. doi: 10.1097/00000539-199903000-00041.
Postanesthetic shivering (PS) is distressing for patients and may induce a variety of complications. In this prospective, double-blinded, randomized study, we evaluated the value of nalbuphine, compared with meperidine and saline, for treating PS. Ninety adult patients were included in the study. Group 1 (n = 30) received i.v. nalbuphine 0.08 mg/kg, Group 2 (n = 30) received i.v. meperidine 0.4 mg/kg, and Group 3 (n = 30) received i.v. saline. Treatment that stopped shivering was considered to have been successful. The results demonstrated that, 5 min after treatment, both nalbuphine and meperidine provided a rapid and potent anti-shivering effect on PS, with high response rates of 80% and 83%, compared with those of saline (0%) (P < 0.01). Thirty minutes after injection, the response rates of nalbuphine and meperidine were 90% and 93%, respectively, compared with 17% in the saline group (P < 0.01). The differences between nalbuphine and meperidine were not significant. We conclude that nalbuphine may be an alternative to meperidine for treating PS.
We evaluated nalbuphine versus meperidine and saline for treating postanesthetic shivering. Our results demonstrate that both nalbuphine and meperidine provide a similar rapid and potent anti-shivering effect. Nalbuphine may be an alternative to meperidine for treating postanesthetic shivering.
麻醉后寒战（PS）让患者痛苦，且可能引发多种并发症。在这项前瞻性、双盲、随机研究中，我们评估了与哌替啶和生理盐水相比，纳布啡治疗PS的价值。90名成年患者纳入本研究。第1组（n = 30）静脉注射0.08 mg/kg纳布啡，第2组（n = 30）静脉注射0.4 mg/kg哌替啶，第3组（n = 30）静脉注射生理盐水。能止住寒战的治疗被视为成功。结果表明，治疗后5分钟，纳布啡和哌替啶对PS均有快速且有效的抗寒战作用，有效率分别为80%和83%，而生理盐水组为0%（P < 0.01）。注射后30分钟，纳布啡和哌替啶的有效率分别为90%和93%，生理盐水组为17%（P < 0.01）。纳布啡与哌替啶之间的差异不显著。我们得出结论，纳布啡可能是治疗PS时哌替啶的替代药物。
我们评估了纳布啡与哌替啶和生理盐水治疗麻醉后寒战的效果。我们的结果表明，纳布啡和哌替啶都具有相似的快速且有效的抗寒战作用。纳布啡可能是治疗麻醉后寒战时哌替啶的替代药物。
