Takai-Igarashi T, Nadaoka Y, Kaminuma T
Division of Chem-Bio Informatics, National Institute of Health Sciences, Setagaya, Tokyo, Japan.
J Comput Biol. 1998 Winter;5(4):747-54. doi: 10.1089/cmb.1998.5.747.
We developed a data and knowledge base for cellular signal transduction in human cells, to make this rapidly growing information available. The database includes all the biological properties of cellular signal transduction, including biological reactions that transfer cellular signals and molecular attributes characterized by sequences, structures, and functions. Since the database is based on the object-oriented technique, highly flexible methods of data definition and modification are necessary to handle this diverse and complex biological information. The database includes attractive graphical representations of signaling cascades and the three-dimensional structure of molecules. The database is a novel application of ACEDB, which was the database originally developed to store the C. elegans genome. The database can be accessed through the Internet at http://geo.nihs.go.jp/csndb.html.
我们开发了一个关于人类细胞中细胞信号转导的数据和知识库，以使这一快速增长的信息能够被获取。该数据库涵盖了细胞信号转导的所有生物学特性，包括传递细胞信号的生物学反应以及以序列、结构和功能为特征的分子属性。由于该数据库基于面向对象技术，因此需要高度灵活的数据定义和修改方法来处理这种多样且复杂的生物学信息。该数据库包含了信号级联反应和分子三维结构的吸引人的图形表示。该数据库是ACEDB的一种新应用，ACEDB最初是为存储秀丽隐杆线虫基因组而开发的数据库。可通过互联网在http://geo.nihs.go.jp/csndb.html访问该数据库。
