Rohl Carol, Price Yancey, Fischer Tiffany B, Paczkowski Melissa, Zettel Michael F, Tsai Jerry
Rosetta Inpharmatics LLC, Seattle, WA, USA.
Mol Biotechnol. 2006 Sep;34(1):69-93. doi: 10.1385/MB:34:1:69.
By organizing and making widely accessible the increasing amounts of data from high-throughput analyses, protein interaction databases have become an integral resource for the biological community in relating sequence data with higher-order function. To provide a sense of the use and applicability of these databases, we describe each of the major comprehensive interaction databases as well as some of the more specialized ones. Content description, search/browse functionalities, and data presentation are discussed. A succinct explanation of database contents helps the user quickly identify whether the database contains applicable information to their research interest. Broad levels of search/browse functions as well as descriptions/examples allow users to quickly find and access pertinent data. At this point, clear presentation of search results as well as the primary content is necessary. Many databases display information graphically or divided into smaller digestible parts over a number of tabbed/linked pages. In addition, cross-linking between the databases promotes interconnectivity of the data and is an added layer of relational data for the user. Overall, although these protein interaction databases are under continual improvement, their current state shows that much time and effort has gone into organizing and presenting these large sets of data-describing protein interactions.
通过整理高通量分析产生的越来越多的数据并使其广泛可用，蛋白质相互作用数据库已成为生物界将序列数据与高阶功能联系起来的不可或缺的资源。为了让大家了解这些数据库的用途和适用性，我们描述了每个主要的综合相互作用数据库以及一些更具专业性的数据库。我们讨论了内容描述、搜索/浏览功能以及数据呈现方式。对数据库内容的简要解释有助于用户快速确定该数据库是否包含与其研究兴趣相关的适用信息。广泛的搜索/浏览功能以及描述/示例能让用户快速找到并获取相关数据。此时，清晰呈现搜索结果以及主要内容很有必要。许多数据库以图形方式显示信息，或者在多个标签式/链接页面中将其分成较小的、易于理解的部分。此外，数据库之间的交叉链接促进了数据的互连性，为用户增加了一层关系数据。总体而言，尽管这些蛋白质相互作用数据库在不断改进，但它们目前的状态表明，在整理和呈现这些描述蛋白质相互作用的大量数据方面已经投入了大量时间和精力。
