Wingender E, Chen X, Hehl R, Karas H, Liebich I, Matys V, Meinhardt T, Prüss M, Reuter I, Schacherer F
Gesellschaft für Biotechnologische Forschung mbH, Mascheroder Weg 1, D-38124 Braunschweig, Germany.
Nucleic Acids Res. 2000 Jan 1;28(1):316-9. doi: 10.1093/nar/28.1.316.
TRANSFAC is a database on transcription factors, their genomic binding sites and DNA-binding profiles (http://transfac.gbf.de/TRANSFAC/). Its content has been enhanced, in particular by information about training sequences used for the construction of nucleotide matrices as well as by data on plant sites and factors. Moreover, TRANSFAC has been extended by two new modules: PathoDB provides data on pathologically relevant mutations in regulatory regions and transcription factor genes, whereas S/MARt DB compiles features of scaffold/matrix attached regions (S/MARs) and the proteins binding to them. Additionally, the databases TRANSPATH, about signal transduction, and CYTOMER, about organs and cell types, have been extended and are increasingly integrated with the TRANSFAC data sources.
TRANSFAC是一个关于转录因子、其基因组结合位点和DNA结合图谱的数据库(http://transfac.gbf.de/TRANSFAC/)。其内容得到了扩充,特别是增加了用于构建核苷酸矩阵的训练序列信息以及植物位点和因子的数据。此外,TRANSFAC已通过两个新模块进行了扩展:PathoDB提供调控区域和转录因子基因中与病理相关的突变数据,而S/MARt DB汇编了支架/基质附着区域(S/MARs)及其结合蛋白的特征。此外,关于信号转导的TRANSPATH数据库和关于器官与细胞类型的CYTOMER数据库也得到了扩展,并越来越多地与TRANSFAC数据源整合。