Chotai J, Asberg M
Department of Psychiatry, University of Umeå and Lycksele Hospital, Lycksele, Sweden.
Neuropsychobiology. 1999;39(2):57-62. doi: 10.1159/000026561.
The cerebrospinal fluid (CSF) concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) as well as their ratios and correlations were analyzed in relation to the season of birth. The sample consisted of 241 drug-free patients participating in psychobiological programs and comprising the DSM-III-R diagnoses of mood, anxiety and adjustment disorders. Significant season-of-birth variations were found even after adjusting for sex, age, height, the diagnostic category and the month of lumbar puncture. Those born during February to April had significantly lower values of 5-HIAA. Values of HVA and of the ratios HVA/5-HIAA and HVA/MHPG were significantly higher for those born during October to January. Correlation coefficients also showed season-of-birth variations. These results may provide an important link for the season-of-birth variations reported for several neuropsychiatric disorders.
分析了单胺代谢产物5-羟吲哚乙酸（5-HIAA）、高香草酸（HVA）和3-甲氧基-4-羟基苯乙二醇（MHPG）的脑脊液（CSF）浓度及其比率和相关性与出生季节的关系。样本包括241名未服用药物的患者，他们参与了心理生物学项目，包括DSM-III-R诊断的情绪、焦虑和适应障碍。即使在对性别、年龄、身高、诊断类别和腰椎穿刺月份进行校正后，仍发现了显著的出生季节差异。2月至4月出生的人5-HIAA值显著较低。10月至1月出生的人HVA值以及HVA/5-HIAA和HVA/MHPG比率显著较高。相关系数也显示出出生季节差异。这些结果可能为几种神经精神疾病报告的出生季节差异提供重要联系。
