Neuhaus H, Rosen V, Thies R S
Genetics Institute Inc., 87 Cambridge Park Drive, Cambridge, MA 02140, USA.
Mech Dev. 1999 Feb;80(2):181-4. doi: 10.1016/s0925-4773(98)00221-4.
Here we report the cloning and expression of murine BMP-10, a novel member of the TGF-beta superfamily. In the mouse embryo, BMP-10 expression begins at 9.0 d.p.c. and is restricted to the developing heart. Initially, BMP-10 expression localizes to the trabeculated part of the common ventricular chamber and to the bulbus cordis region. After 12.5 d.p.c., additional BMP-10 expression is seen in the atrial wall. The data presented here suggest that BMP-10 plays an important role in trabeculation of the embryonic heart.
在此，我们报道了小鼠BMP-10（转化生长因子-β超家族的一个新成员）的克隆及表达。在小鼠胚胎中，BMP-10的表达始于胚胎第9.0天，且局限于发育中的心脏。起初，BMP-10的表达定位于共同心室腔的小梁化部分以及动脉圆锥区域。在胚胎第12.5天后，心房壁中可见额外的BMP-10表达。此处呈现的数据表明，BMP-10在胚胎心脏的小梁化过程中发挥重要作用。
