Zhang Z, Zhang J, Wu J
Department of Pathology, Shanghai Medical College for Health Staff.
Zhonghua Bing Li Xue Za Zhi. 1997 Jun;26(3):141-3.
To investigate the relationship between type IV collagenase and basement membrane (BM) and the relationship between type IV collagenase and p21 expression.
Immunohistochemical double labelling technique was used to study paraffin embedded sections of 86 cases of colon carcinoma.
The positive rate of type IV collagenase was 83.72% in carcinoma cases and 10% in normal colorectal mucosa (P < 0.01). Intact BM was seen in normal colorectal mucosa while BM was disrupted and fragmentary in carcinoma cases. A close positive correlation was also found between the expression of type IV collagenase and p21 in colonic carcinoma (r = 0.974, P < 0.01).
The results suggest that type IV collagenase plays an important role in the destruction of BM and invasion by colonic carcinoma.
研究IV型胶原酶与基底膜（BM）之间的关系以及IV型胶原酶与p21表达之间的关系。
采用免疫组织化学双重标记技术研究86例结肠癌石蜡包埋切片。
IV型胶原酶在癌组织中的阳性率为83.72%，在正常大肠黏膜中的阳性率为10%（P<0.01）。正常大肠黏膜可见完整的基底膜，而癌组织中的基底膜被破坏且呈碎片状。在结肠癌中还发现IV型胶原酶的表达与p21之间存在密切的正相关（r=0.974，P<0.01）。
结果表明IV型胶原酶在结肠癌破坏基底膜和侵袭过程中起重要作用。
