Nosten F, Hien T T, White N J
Faculty of Tropical Medicine, Madihol University, Bangkok, Thailand.
Med Trop (Mars). 1998;58(3 Suppl):45-9.
Since 1994, the combination of mefloquine and artesunate is the standard treatment for uncomplicated Plasmodium falciparum malaria in the population of displaced persons on the Western border of Thailand. As a result, the fall of mefloquine efficacy was stopped and the incidence of falciparum malaria reduced. This is attributed to the effects of the artemisinin derivatives on transmissibility. Similar trends were observed in Vietnam where artemisinin is widely used. Combination therapies that include an artemisinin derivative could have a major role in the control of malaria and the spread of drug resistance.
自1994年以来，甲氟喹和青蒿琥酯联合用药一直是泰国西部边境流离失所人群中非复杂性恶性疟原虫疟疾的标准治疗方法。因此，甲氟喹疗效下降的趋势得到了遏制，恶性疟发病率降低。这归因于青蒿素衍生物对传播性的影响。在广泛使用青蒿素的越南也观察到了类似趋势。包含青蒿素衍生物的联合疗法可能在疟疾控制和耐药性传播方面发挥重要作用。
