Eldridge R, McFarland H, Sever J, Sadowsky D, Krebs H
Ann Neurol. 1978 Jan;3(1):72-80. doi: 10.1002/ana.410030111.
Evaluation of presumed "multiple sclerosis families" and comparison with recently reported families has led us to the following observations: (1) Seven of our original fourteen presumptive multiple sclerosis families had to be eliminated after personal clinical evaluation of family members failed to confirm the diagnosis in a second close relative. (2) No segregation of HLA type was noted between affected and unaffected individuals in our seven bona fide multiple sclerosis families, and no consistent segregation was noted in the twenty-eight families reported elsewhere. This supports other genetic evidence that there is not a single, major gene mapping in the HLA complex which predisposes to multiple sclerosis. (3) The DW2 antigen was increased in frequency among affected members of our families, and the A3 B7 haplotype was more frequent among affected members of other families reported. But unaffected members also tended to have an increased frequency of these same antigens. (4) No relationship was noted between HLA type and antimeasles antibody titer within our families.
对假定的“多发性硬化症家族”进行评估并与最近报道的家族进行比较后，我们得出了以下观察结果：(1) 在对家族成员进行个人临床评估后，我们最初的14个假定多发性硬化症家族中有7个因未能在第二位近亲中确诊而被排除。(2) 在我们7个真正的多发性硬化症家族中，未发现患病个体与未患病个体之间存在HLA类型的分离，在其他地方报道的28个家族中也未发现一致的分离现象。这支持了其他遗传证据，即HLA复合体中不存在单一的主要基因图谱易导致多发性硬化症。(3) 我们家族中患病成员的DW2抗原频率增加，在其他报道的家族中，患病成员中A3 B7单倍型更为常见。但未患病成员也倾向于有这些相同抗原的频率增加。(4) 在我们家族中，未发现HLA类型与抗麻疹抗体滴度之间存在关联。
