Jersild C
Boll Ist Sieroter Milan. 1978 Jan 31;56(6):516-30.
This review describes the presently available data on HLA typing in patients with multiple sclerosis (MS). Almost 2,000 MS patients and 12,000 normal controls have been studied with HLA typing in 15 different laboratories. The combined data show remarkably homogeneous results, and are as summarized: an increased frequency of HLA-Dw2 of B7, B8, Bw18, A3, and A1. A decreased frequency of A2, A28, B12, Bw15, Bw17, Bw22, and Bw40. Analysis of data seems to indicate that the HLA linked MS susceptibility gene is linked to HLA-Dw2, and the other deviating HLA antigen frequencies, except B8, may be explained as a secondary phenomenon, due to linkage disequilibrium. The presented data do not allow any conclusions as to whether the MS susceptibility gene operates in a dominant or recessive way. The important of HLA as a marker for disease and MS in particular is discussed, and preliminary data on HLA studies of MS patients of other ethnic groups, notably American blacks, seem to indicate that genetically determined ethnic differences, notably those of HLA, may partly be responsible for the unique geographic distribution of the disease.
这篇综述描述了目前关于多发性硬化症（MS）患者 HLA 分型的现有数据。在 15 个不同实验室中，对近 2000 例 MS 患者和 12000 例正常对照进行了 HLA 分型研究。综合数据显示出非常一致的结果，总结如下：B7、B8、Bw18、A3 和 A1 的 HLA-Dw2 频率增加。A2、A28、B12、Bw15、Bw17、Bw22 和 Bw40 的频率降低。数据分析似乎表明，与 HLA 相关的 MS 易感基因与 HLA-Dw2 相关联，除 B8 外，其他偏离的 HLA 抗原频率可能是由于连锁不平衡导致的次要现象。所呈现的数据无法就 MS 易感基因是以显性还是隐性方式起作用得出任何结论。文中讨论了 HLA 作为疾病尤其是 MS 的标志物的重要性，关于其他种族群体（尤其是美国黑人）MS 患者 HLA 研究的初步数据似乎表明，基因决定的种族差异，尤其是 HLA 方面的差异，可能部分导致了该疾病独特的地理分布。
