人乳头瘤病毒31b型上游调控区域中的两个新型启动子受上皮分化的负调控。
Two novel promoters in the upstream regulatory region of human papillomavirus type 31b are negatively regulated by epithelial differentiation.
作者信息
Ozbun M A, Meyers C
机构信息
Department of Molecular Genetics and Microbiology, The University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA.
出版信息
J Virol. 1999 Apr;73(4):3505-10. doi: 10.1128/JVI.73.4.3505-3510.1999.
Abstract
Organotypic cultures support the stratification and differentiation of keratinocytes and the human papillomavirus (HPV) life cycle. We report transcription from four novel promoters in the HPV31b upstream regulatory region during the viral life cycle in organotypic cultures. Promoter initiation was not differentiation dependent; two promoters were down-regulated upon epithelial differentiation.
摘要
器官型培养支持角质形成细胞的分层和分化以及人乳头瘤病毒（HPV）的生命周期。我们报告了在器官型培养的病毒生命周期中，HPV31b上游调控区域四个新启动子的转录情况。启动子起始不依赖于分化；两个启动子在上皮分化时被下调。
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