Wang Z, Young L J, De Vries G J, Insel T R
Department of Psychology, Florida State University, Tallahassee 32306-1270, USA.
Prog Brain Res. 1998;119:483-99. doi: 10.1016/s0079-6123(08)61589-7.
Several lines of evidence have implicated the neurohypophyseal peptide, vasopressin (VP), in the mediation of complex social behaviors including affiliation, aggression, juvenile recognition and parental behavior. Recent studies in microtine rodents using cellular, molecular and behavioral approaches provide additional evidence suggesting a role for VP in the formation of pair bonding and male parental care. Monogamous and promiscuous voles differ in social behaviors such as mating-induced pair bonding, selective aggression, and male parental care. Comparative studies have demonstrated that they also differ in dynamics of VP synthesis and release associated with reproduction, in the distribution pattern and regional quantity of VP receptors, and in the promoter sequence of the V1a receptor gene. In monogamous prairie voles, (Microtus ochrogaster), brain administration of VP induces pair bonding and male parental care whereas administration of the VP antagonist diminishes these behaviors. Together, these data suggest that VP is involved in the regulation of social behaviors in monogamous voles and differences in the brain VP system may underlie species differences in behavior and life strategy in voles.
多项证据表明，神经垂体肽血管加压素（VP）参与介导包括依恋、攻击、幼崽识别和育儿行为在内的复杂社会行为。最近在田鼠类啮齿动物中使用细胞、分子和行为学方法进行的研究提供了更多证据，表明VP在配偶关系形成和雄性育儿行为中发挥作用。一夫一妻制和滥交的田鼠在社会行为上存在差异，如交配诱导的配偶关系、选择性攻击和雄性育儿行为。比较研究表明，它们在与繁殖相关的VP合成和释放动态、VP受体的分布模式和区域数量以及V1a受体基因的启动子序列方面也存在差异。在一夫一妻制的草原田鼠（Microtus ochrogaster）中，向大脑注射VP会诱导配偶关系和雄性育儿行为，而注射VP拮抗剂则会减少这些行为。总之，这些数据表明VP参与了一夫一妻制田鼠社会行为的调节，大脑VP系统的差异可能是田鼠行为和生活策略物种差异背后的原因。
