Gutin B, Ramsey L, Barbeau P, Cannady W, Ferguson M, Litaker M, Owens S
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, USA.
Am J Clin Nutr. 1999 Mar;69(3):388-94. doi: 10.1093/ajcn/69.3.388.
Little is known about the effects of physical training on plasma leptin concentrations in children.
We sought to determine the effects of 4-mo periods with and without physical training on leptin in obese children and to explore the determinants of leptin at baseline and in response to physical training.
Participants were 34 obese 7-11-y-old children randomly assigned to engage in physical training during either the first or second 4 mo of the 8-mo study.
Total body composition, visceral adiposity, and insulin were all positively correlated with leptin at baseline (P < or = 0.05); however, only fat mass was retained in the final stepwise regression (P = 0.0001, R2 = 0.57). Leptin decreased during the 4-mo periods of physical training and increased in the 4 mo after cessation of physical training (P < 0.001 for the time by group interaction). Decreases in leptin were greatest in children with higher pretraining leptin concentrations, those whose total mass increased least, and those whose insulin concentrations decreased most (P < or = 0.05); only pretraining leptin concentration (P = 0.009) and change in total mass (P = 0.0002) were retained in the final regression (R2 = 0.53).
In obese children, leptin concentration decreased during 4 mo of physical training and increased during a subsequent 4-mo period without physical training, fat mass was highly correlated with baseline leptin, and greater reductions in leptin during 4 mo of physical training were seen in children with higher pretraining leptin and in those whose total mass increased least.
关于体育锻炼对儿童血浆瘦素浓度的影响，人们所知甚少。
我们试图确定在肥胖儿童中，进行4个月体育锻炼和不进行体育锻炼对瘦素的影响，并探究基线时以及体育锻炼后瘦素的决定因素。
34名7至11岁的肥胖儿童参与了这项为期8个月的研究，他们被随机分配在8个月中的前4个月或后4个月进行体育锻炼。
基线时，总体成分、内脏脂肪量和胰岛素均与瘦素呈正相关（P≤0.05）；然而，最终逐步回归分析中仅保留了脂肪量（P = 0.0001，R2 = 0.57）。在体育锻炼的4个月期间瘦素下降，停止体育锻炼后的4个月中瘦素升高（时间与组间交互作用，P < 0.001）。瘦素下降幅度最大的是那些训练前瘦素浓度较高、总体质量增加最少以及胰岛素浓度下降最多的儿童（P≤0.05）；最终回归分析中仅保留了训练前瘦素浓度（P = 0.009）和总体质量变化（P = 0.0002）（R2 = 0.53）。
在肥胖儿童中，体育锻炼的4个月期间瘦素浓度下降，随后4个月不进行体育锻炼时瘦素浓度升高，脂肪量与基线瘦素高度相关，训练前瘦素较高以及总体质量增加最少的儿童在体育锻炼的4个月期间瘦素下降幅度更大。
