Barbeau Paule, Gutin Bernard, Litaker Mark S, Ramsey Leigh T, Cannady William E, Allison Jerry, Lemmon Christian R, Owens Scott
Georgia Prevention Institute, Dept Pediatrics, Medical Coll. of Georgia, HS 1640, 1499 Walton Way, Augusta, GA 30912-3710, USA.
Can J Appl Physiol. 2003 Jun;28(3):382-96. doi: 10.1139/h03-028.
Little is known about the effects of different intensities of physical training on plasma leptin. This study examined the effect of two intensities of physical training on leptin in obese teenagers, and explored correlates at baseline and in response to 8 months of physical training. The participants were 55 obese youths 12-16 years of age who completed both baseline and posttesting. The youths were randomized to engage in lifestyle education only (LSE), moderate-intensity physical training and LSE, or high-intensity physical training and LSE. Baseline leptin was positively associated with fat mass. Girls had higher leptin levels at lower levels of fasting insulin than boys. The 8-mo physical training doses prescribed to obese teenagers did not result in significant group differences in mean change in leptin, although there was large variability in individual response. The change in leptin was inversely associated with baseline leptin and change in cardiovascular fitness. Diet, physical activity level, visceral adiposity, and glucose concentrations were not associated with leptin, neither at baseline nor in response to physical training. At baseline, total fat mass rather than visceral adiposity was associated with higher leptin levels. Over the 8-mo intervention period, regardless of group membership, youths who had the lowest increase in cardiovascular fitness tended to have the highest increase in leptin.
关于不同强度体育锻炼对血浆瘦素的影响，人们了解甚少。本研究考察了两种强度的体育锻炼对肥胖青少年瘦素的影响，并探讨了基线水平以及8个月体育锻炼后的相关因素。参与者为55名12至16岁的肥胖青少年，他们均完成了基线测试和后期测试。这些青少年被随机分为仅接受生活方式教育组（LSE）、中等强度体育锻炼加LSE组，或高强度体育锻炼加LSE组。基线瘦素水平与脂肪量呈正相关。在空腹胰岛素水平较低时，女孩的瘦素水平高于男孩。尽管个体反应存在较大差异，但规定给肥胖青少年的8个月体育锻炼剂量并未导致各组瘦素平均变化出现显著差异。瘦素的变化与基线瘦素水平以及心血管健康状况的变化呈负相关。饮食、身体活动水平、内脏脂肪量和血糖浓度在基线时以及体育锻炼后均与瘦素无关。在基线时，总脂肪量而非内脏脂肪量与较高的瘦素水平相关。在8个月的干预期内，无论所属组别如何，心血管健康状况增幅最小的青少年往往瘦素增幅最大。
