González A G, Alvarenga N L, Bazzocchi I L, Ravelo A G, Moujir L
Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Tenerife, Canary Islands, Spain.
Planta Med. 1998 Dec;64(8):769-71. doi: 10.1055/s-2006-957581.
By antimicrobial and cytotoxic-guided fractionation, a bioactive norquinone-methide triterpene, 15 alpha-hydroxypristimerin, was isolated from a South American medicinal plant, Maytenus scutioides. Its structure was determined on the basis of spectroscopic evidence. Successful chemical transformation of pristimerin to netzahualcoyene indicates that the 15-hydroxy compounds seems to be a possible percursor of 14(15)-ene-quinone-methide-triterpenoids in the biogenetic pathway.
通过抗菌和细胞毒性导向的分级分离，从一种南美药用植物马滕斯氏刺榄（Maytenus scutioides）中分离出一种生物活性的降醌甲基三萜，15α-羟基扁蒴藤素。其结构基于光谱证据确定。扁蒴藤素成功化学转化为奈扎瓦尔科约烯表明，在生物合成途径中，15-羟基化合物似乎是14(15)-烯-醌甲基-三萜类化合物的可能前体。
