Sideroxylonal C, a new inhibitor of human plasminogen activator inhibitor type-1, from the flowers of Eucalyptus albens.
作者信息
Neve J, Leone P A, Carroll A R, Moni R W, Paczkowski N J, Pierens G, Björquist P, Deinum J, Ehnebom J, Inghardt T, Guymer G, Grimshaw P, Quinn R J
机构信息
Queensland Pharmaceutical Research Institute, Griffith University, Brisbane, 4111, Australia.
出版信息
J Nat Prod. 1999 Feb;62(2):324-6. doi: 10.1021/np980286+.
PMID:10075775
Abstract
Sideroxylonal C (3), a new phloroglucinol dimer, was isolated from the flowers of Eucalyptus albens through bioassay-guided fractionation. The structure elucidation was based on 1D and 2D NMR experiments, MS analysis, and comparison with sideroxylonals A (1) and B (2). Sideroxylonal C inhibited human plasminogen activator inhibitor type-1 at 4.7 microM without any significant effect on human tissue plasminogen activator.
摘要
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