Carney J R, Krenisky J M, Williamson R T, Luo J, Carlson T J, Hsu V L, Moswa J L
Shaman Pharmaceuticals, Inc., 213 E. Grand Ave., South San Francisco, California 94080, USA.
J Nat Prod. 1999 Feb;62(2):345-7. doi: 10.1021/np980356c.
Bioassay-guided fractionation of the EtOH extract of M. africana, using the in vivo noninsulin-dependent diabetes mellitus db/db mouse model, resulted in the isolation of the new daphnane-type diterpenoid maprouneacin (2). Compound 2 showed potent glucose-lowering properties when given by the oral route.
