School of Pharmacy, College of Medicine, National Taiwan University, 1 Jen-Ai Road, Taipei 10051, Taiwan, Republic of China.
J Nat Prod. 2012 Feb 24;75(2):153-9. doi: 10.1021/np200692v. Epub 2012 Jan 27.
Three new diterpenoids, 2-O-lactoylborapetoside B (1), 6'-O-lactoylborapetoside B (2), and tinocrispol A (3), and nine known diterpenoids (4-12) were isolated from an EtOH extract of Tinospora crispa vines. Their structures were elucidated by spectroscopic analyses. The C-6 glucosyloxy group in borapetoside C (6) was revised to be α-oriented. The in vivo hypoglycemic activities of the major components, borapetosides A-C (4-6), were examined. Intraperitoneal injection of 4 and 6 (5 mg/kg) showed significant lowering of plasma glucose levels in normal and streptozotocin-induced type 1 diabetic mice. Borapetoside C increased glucose utilization in peripheral tissues and reduced hepatic gluconeogenesis, accounting for the hypoglycemic effect.
从三叶崖爬藤藤茎的乙醇提取物中分离得到了 3 个新二萜类化合物，2-O-乳酰波紫檀苷 B（1）、6'-O-乳酰波紫檀苷 B（2）和锡诺克里斯波尔 A（3），以及 9 个已知的二萜类化合物（4-12）。通过光谱分析阐明了它们的结构。对波紫檀苷 C（6）中的 C-6 葡萄糖氧基进行了修订，确定其为α-构型。研究了主要成分波紫檀苷 A-C（4-6）的体内降血糖活性。4 和 6（5mg/kg）的腹腔注射可显著降低正常和链脲佐菌素诱导的 1 型糖尿病小鼠的血糖水平。波紫檀苷 C 增加外周组织的葡萄糖利用并减少肝糖异生，从而发挥降血糖作用。
