Ubillas R P, Mendez C D, Jolad S D, Luo J, King S R, Carlson T J, Fort D M
Planta Med. 2000 Feb;66(1):82-3. doi: 10.1055/s-0029-1243117.
In vivo bioassay-guided fractionation of the aqueous alcohol extract of the aerial parts of Bidens pilosa Sch. Bip. var. radiata (Asteraceae) using C57 BL/Ks-db/db mice as a model for type 2 diabetes, yielded two known polyacetylenic glucosides, identified as 2-beta-D-glucopyranosyloxy-1-hydroxy-5(E)-tridecene-7,9,11-+ ++triyne (1) and 3-beta-D-glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,1 2-triyne (2). A 3:2 mixture of compounds 1 and 2 effected a significant drop in blood glucose.
以C57 BL/Ks-db/db小鼠作为2型糖尿病模型，对鬼针草地上部分的水醇提取物进行体内生物测定导向的分离，得到了两种已知的聚乙炔基葡萄糖苷，分别鉴定为2-β-D-吡喃葡萄糖氧基-1-羟基-5（E）-十三碳烯-7,9,11-三炔（1）和3-β-D-吡喃葡萄糖氧基-1-羟基-6（E）-十四碳烯-8,10,12-三炔（2）。化合物1和2的3:2混合物使血糖显著下降。
