Fuso L, Marini M, Marzano M, Nardecchia B, Roda L G, Rossi P, Urbani A
Fisiopatologia Respiratoria, Università Cattolica del Sacro Cuore, Rome, Italy.
Clin Immunol. 1999 Mar;90(3):411-9. doi: 10.1006/clim.1998.4667.
Plasma hydrolysis of leucine enkephalin was studied in a group of patients affected by seasonal allergic asthma in acute and quiescent stage; data were compared with those obtained from a control group of healthy volunteers. Results obtained indicate a statistically significant reduction of leu-enkephalin hydrolysis in allergic subjects. In the quiescent stage, substrate degradation is reduced, and the pattern of the hydrolysis by-products is modified with respect to normal controls. In the acute stage, hydrolysis is further reduced, and the pattern of the hydrolysis by-products is further modified with respect to the quiescent stage. The variations of leu-enkephalin hydrolysis appear to be controlled by decreased activity of proteolytic enzymes and by increased activity of the low-molecular-weight plasma inhibitors active on these enzymes. The sum of these processes is conducive to a distribution of enkephalin-hydrolyzing enzymes, as well as a hydrolysis pattern, that appears to be specific for the allergic subjects and distinct from that seen in the controls.
对一组处于急性发作期和缓解期的季节性过敏性哮喘患者的亮氨酸脑啡肽血浆水解情况进行了研究；将数据与一组健康志愿者对照组的数据进行了比较。所得结果表明，过敏受试者中亮氨酸脑啡肽水解有统计学上的显著降低。在缓解期，底物降解减少，水解副产物的模式相对于正常对照组有所改变。在急性期，水解进一步减少，水解副产物的模式相对于缓解期进一步改变。亮氨酸脑啡肽水解的变化似乎受蛋白水解酶活性降低以及对这些酶有活性的低分子量血浆抑制剂活性增加的控制。这些过程的总和有利于脑啡肽水解酶的分布以及水解模式，这似乎是过敏受试者所特有的，且与对照组不同。
