中年女性样本中的铅与高血压
Lead and hypertension in a sample of middle-aged women.
作者信息
Korrick S A, Hunter D J, Rotnitzky A, Hu H, Speizer F E
机构信息
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
Am J Public Health. 1999 Mar;89(3):330-5. doi: 10.2105/ajph.89.3.330.
OBJECTIVES
The role of lead exposure as a risk factor for hypertension is less well defined among women than among men. This case-control study assessed the relation of blood and bone lead concentrations to hypertension in women.
METHODS
Cases and controls were a subsample of women from the Nurses' Health Study. Hypertension was defined as a physician diagnosis of hypertension between 1988 and 1994 or measured systolic blood pressure > or = 140 mm Hg or diastolic blood pressure > or = 90 mm Hg.
RESULTS
Mean (SD) blood lead concentration was 0.15 (0.11) mumol/L; mean tibia and patella lead concentrations by K-x-ray fluorescence were 13.3 (9.0) and 17.3 (11.1) micrograms/g, respectively. After adjustment for potentially confounding factors, an increase from the 10th to the 90th percentile of patella lead values (25 micrograms/g) was associated with approximately 2-fold (95% confidence interval = 1.1, 3.2) increased risk of hypertension. There was no association between hypertension and either blood or tibia lead concentrations.
CONCLUSIONS
These findings support a potentially important role for low-level lead exposure as a risk factor for hypertension among non-occupationally exposed women.
目的
铅暴露作为高血压风险因素在女性中的作用不如在男性中明确。本病例对照研究评估了女性血液和骨骼铅浓度与高血压之间的关系。
方法
病例和对照是护士健康研究中女性的一个子样本。高血压定义为1988年至1994年间医生诊断的高血压，或测量的收缩压≥140毫米汞柱或舒张压≥90毫米汞柱。
结果
平均（标准差）血铅浓度为0.15（0.11）微摩尔/升；通过K-X射线荧光法测得的胫骨和髌骨平均铅浓度分别为13.3（9.0）和17.3（11.1）微克/克。在对潜在混杂因素进行调整后，髌骨铅值从第10百分位数增加到第90百分位数（25微克/克）与高血压风险增加约2倍（95%置信区间=1.1, 3.2）相关。高血压与血铅浓度或胫骨铅浓度之间均无关联。
结论
这些发现支持低水平铅暴露作为非职业暴露女性高血压风险因素的潜在重要作用。
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