Cake K M, Bowins R J, Vaillancourt C, Gordon C L, McNutt R H, Laporte R, Webber C E, Chettle D R
Department of Physics & Astronomy, McMaster University, Hamilton, Ontario, Canada.
Am J Ind Med. 1996 May;29(5):440-5. doi: 10.1002/(SICI)1097-0274(199605)29:5<440::AID-AJIM2>3.0.CO;2-Q.
Serum lead, whole blood lead, and lead in both tibia and calcaneus were measured in each of 49 active lead workers. Serum lead correlated more strongly with both in vivo bone lead measurements than did whole blood lead. The ratio of serum lead to whole blood lead varied from 0.8% to 2.5% and showed a positive correlation with tibia, and an even stronger correlation with calcaneus lead. This implies that lead released from bone (endogenous exposure) results in a higher proportion of whole blood lead being in serum than is the case for exogenous exposure. This observation needs to be confirmed, and the relationships amongst the parameters must be studied further, particularly in former or retired lead workers. If confirmed, since at least a portion of lead in serum is readily diffusible and thus toxicologically more immediately significant than lead bound to red cells, the health implications of endogenous exposure may have to be reassessed.
对49名在职铅作业工人分别测量了血清铅、全血铅以及胫骨和跟骨中的铅含量。血清铅与体内骨铅测量值的相关性比全血铅更强。血清铅与全血铅的比值在0.8%至2.5%之间变化，与胫骨铅呈正相关，与跟骨铅的相关性更强。这意味着从骨骼中释放的铅（内源性暴露）导致血清中全血铅的比例高于外源性暴露的情况。这一观察结果需要得到证实，并且必须进一步研究这些参数之间的关系，特别是在以前或退休的铅作业工人中。如果得到证实，由于血清中至少一部分铅易于扩散，因此在毒理学上比与红细胞结合的铅更具即时重要性，内源性暴露对健康的影响可能需要重新评估。
