Menditto A, Morisi G, Spagnolo A, Menotti A
Laboratorio di Biochimica Clinica, Istituto Superiore di Sanità, Rome, Italy.
Environ Health Perspect. 1994 Nov;102 Suppl 9(Suppl 9):107-11. doi: 10.1289/ehp.94102s9107.
The association of blood lead (B-Pb) concentration to blood pressure was investigated in men aged 55 to 75 years living in the Rome area, who had no history of exposure to lead in the workplace and who participated between 1989 and 1990 in an epidemiologic survey for coronary heart disease (New Risk Factor Project). Of the 1856 individuals eligible for the study, 59 were excluded from analyses because not all relevant data were available; and 478 were excluded because they were treated for hypertension. In the remaining subjects (n = 1319) the median B-Pb concentration was 113 micrograms/l (range: 40-442 micrograms/l). Systolic blood pressure (SBP) averaged 140 +/- 18 (standard deviation) mm Hg (range 98-220) and diastolic blood pressure (DBP) 84 +/- 9 mm Hg (range 56-118). Median B-Pb values increased significantly from 111 micrograms/l in subjects with normal blood pressure (n = 668) to 113.5 micrograms/l in subjects with borderline high blood pressure (n = 373) and to 120 micrograms/l in subjects with increased blood pressure (n = 278). After log-normal conversion of B-Pb, the linear correlation coefficient between In[B-Pb(ug/l)] and both SBP and DBP was statistically significant (r = 0.1332, p < 0.001 and r = 0.0737, p = 0.007, respectively). The linear regression coefficient was 6.8 mm Hg/In(micrograms/l) for SBP and 1.8 mm Hg/In(microgram/l) for DBP. Multiple regression analyses revealed that, after correction for body mass index (BMI), age, heart rate, skinfold thickness, serum lipids, and glucose levels; blood lead was still a significant predictor of increased SBP and DBP.(ABSTRACT TRUNCATED AT 250 WORDS)
对居住在罗马地区、年龄在55至75岁之间、无职业铅接触史且于1989年至1990年参与冠心病流行病学调查（新危险因素项目）的男性，研究了血铅（B-Pb）浓度与血压之间的关联。在1856名符合研究条件的个体中，59名因并非所有相关数据都可获取而被排除在分析之外；478名因患有高血压接受治疗而被排除。在其余受试者（n = 1319）中，B-Pb浓度中位数为113微克/升（范围：40 - 442微克/升）。收缩压（SBP）平均为140±18（标准差）毫米汞柱（范围98 - 220），舒张压（DBP）为84±9毫米汞柱（范围56 - 118）。B-Pb值中位数从血压正常的受试者（n = 668）中的111微克/升显著升高至临界高血压受试者（n = 373）中的113.5微克/升，以及血压升高受试者（n = 278）中的120微克/升。对B-Pb进行对数正态转换后，In[B-Pb（微克/升）]与SBP和DBP之间的线性相关系数具有统计学意义（分别为r = 0.1332，p < 0.001和r = 0.0737，p = 0.007）。SBP的线性回归系数为6.8毫米汞柱/In（微克/升），DBP为1.8毫米汞柱/In（微克/升）。多元回归分析显示，在校正体重指数（BMI）、年龄、心率、皮褶厚度、血脂和血糖水平后，血铅仍是SBP和DBP升高的显著预测因素。（摘要截短于250字）
