Mitchell D G, Alam F
Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107, USA.
J Magn Reson Imaging. 1999 Feb;9(2):366-8. doi: 10.1002/(sici)1522-2586(199902)9:2<366::aid-jmri33>3.0.co;2-e.
The purpose of this study was to determine the effects of mangafodipir trisodium on heavily T2-weighted magnetic resonance cholangiography (MRC) images and on functional T1-weighted MRC. Pre- and post-mangafodipir trisodium heavily T2-weighted MRC and fat-suppressed T1-weighted three-dimensional (3D) gradient-echo MRC images were obtained in a patient with a prior cholecystectomy and a long cystic duct remnant that had apparent biliary stasis. Multiplanar reconstructed images were created. The precontrast T2-weighted MRC showed a long cystic duct remnant and a normal common bile duct (CBD). The postcontrast T2-weighted MRC showed loss of CBD signal, but persistent signal in the cystic duct remnant due to biliary stasis. Post-mangafodipir T1-weighted 3D gradient-echo images showed the main right and left hepatic ducts, but the cystic duct was not depicted. Conventional T2-weighted MRC sequences should not be obtained after administering mangafodipir trisodium because this contrast agent decreases the T2 and therefore the signal intensity of bile within normally functioning bile ducts. Functional MRC images can be acquired by using a post-mangafodipir T1-weighted technique.
本研究的目的是确定锰福地匹三钠对重度T2加权磁共振胆管造影（MRC）图像以及功能性T1加权MRC的影响。在一名既往有胆囊切除术且胆囊管残端较长并存在明显胆汁淤积的患者中，获取了注射锰福地匹三钠前后的重度T2加权MRC图像以及脂肪抑制T1加权三维（3D）梯度回波MRC图像。生成了多平面重建图像。注射造影剂前的T2加权MRC显示胆囊管残端较长且胆总管（CBD）正常。注射造影剂后的T2加权MRC显示CBD信号消失，但由于胆汁淤积，胆囊管残端信号持续存在。注射锰福地匹三钠后的T1加权3D梯度回波图像显示了主要的左右肝管，但未显示胆囊管。注射锰福地匹三钠后不应获取常规T2加权MRC序列，因为这种造影剂会降低T2，从而降低正常功能胆管内胆汁的信号强度。功能性MRC图像可通过使用注射锰福地匹三钠后的T1加权技术来获取。
