钆塞酸二钠与锰二吡咯烷二羧酸增强磁共振胆系造影：健康志愿者的对比研究。

Contrast-enhanced MR cholangiography: comparison of Gd-EOB-DTPA and Mn-DPDP in healthy volunteers.

机构信息

Department of Radiology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.

出版信息

Br J Radiol. 2012 Sep;85(1017):1250-4. doi: 10.1259/bjr/22238911. Epub 2012 May 2.

DOI:10.1259/bjr/22238911

PMID:22553292

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3487056/

Abstract

OBJECTIVE

The purpose of this study was to compare the biliary enhancement dynamics of gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic-acid (Gd-EOB-DTPA) and mangafodipir trisodium (Mn-DPDP) for contrast-enhanced MR cholangiography (MRC) in healthy subjects.

METHODS

15 healthy volunteers underwent MRI at 1.5 T with volumetric interpolated breath-hold examination sequence. Each volunteer was scanned once for each contrast agent. The signal-to-noise ratio (SNR) of the liver parenchyma and common hepatic duct (CHD) and the contrast-to-noise ratio (CNR) of CHD to liver parenchyma were evaluated and compared before and at several time points (5, 15, 30, 45, 60, 90, and 120 min) after injection of each agent.

RESULTS

SNR was significantly higher for Gd-EOB-DTPA than for Mn-DPDP in liver parenchyma after 5 min and in CHD after 15 min (p<0.05). CNR of CHD to liver parenchyma using Gd-EOB-DTPA showed an initial decrease at 5 min post-injection followed by a steep increase to a peak at 15 min post-injection. CNR using Mn-DPDP showed a steady increase to a peak at 15 min post-injection without an initial decrease. At 15 min, the value of CNR was significantly higher for Gd-EOB-DTPA than for Mn-DPDP (p<0.05).

CONCLUSION

For both contrast agents, CNR reached a peak at 15 min after contrast injection. At this time point, CNR of Gd-EOB-DTPA was significantly higher than that of Mn-DPDP. Therefore, Gd-EOB-DTPA may provide better contrast-enhanced MRC than Mn-DPDP at 15 min after contrast administration.

摘要

目的

本研究旨在比较钆塞酸二钠（Gd-EOB-DTPA）和锰（Ⅱ）-二乙三胺五乙酸（Mn-DPDP）在健康受试者中对比增强磁共振胆胰管成像（MRC）的胆道增强动力学。

方法

15 名健康志愿者在 1.5T 磁共振仪上进行容积内插屏气检查序列检查。每位志愿者分别对两种造影剂进行一次扫描。在注射后 5、15、30、45、60、90 和 120 分钟的多个时间点，评估和比较肝脏实质和肝总管（CHD）的信噪比（SNR）和 CHD 与肝脏实质的对比噪声比（CNR）。

结果

在注射后 5 分钟，Gd-EOB-DTPA 组肝实质 SNR 明显高于 Mn-DPDP 组，在注射后 15 分钟，CHD SNR 明显高于 Mn-DPDP 组（p<0.05）。使用 Gd-EOB-DTPA 的 CHD 与肝脏实质的 CNR 显示在注射后 5 分钟时先下降，然后在注射后 15 分钟时急剧增加到峰值。使用 Mn-DPDP 的 CNR 显示在注射后 15 分钟时呈稳定增加到峰值，没有先下降。在 15 分钟时，Gd-EOB-DTPA 的 CNR 值明显高于 Mn-DPDP（p<0.05）。