Aime S, Botta M, Geninatti Crich S, Giovenzana G, Palmisano G, Sisti M
Dipartimento di Chimica IFM, Università di Torino, via P. Giuria 7, I-10125 Torino, Italy.
Bioconjug Chem. 1999 Mar-Apr;10(2):192-9. doi: 10.1021/bc980030f.
Macromolecular Gd(III) complexes may find useful application as contrast agents for magnetic resonance angiography (MRA). Herein two novel systems are reported, namely Gd(DO3ASQ)3-lys16 and Gd(DO3ASQ)30-orn114. Their syntheses are based on the ability of the squaric acid moiety to act as a linker between the DO3A (1,4,7, 10-tetraazacyclododecane-1,4,7-triacetic acid) chelate moiety and the polyamino acidic chain. Moreover, the squaric acid participates in the coordination cage of the Gd(III) ion. The investigation of 1H and 17O NMR relaxation processes of solvent water nuclei allowed a detailed characterization of the systems under study. Gd(DO3ASQ)30-orn114 displays a remarkable ability to enhance the water proton relaxation rate of its solutions, and it may be considered as potential contrast agent for MRA applications.
大分子钆（III）配合物可能作为磁共振血管造影（MRA）的造影剂有实用价值。本文报道了两个新体系，即钆（DO3ASQ）3 - 赖氨酸16和钆（DO3ASQ）30 - 鸟氨酸114。它们的合成基于方酸部分作为DO3A（1,4,7,10 - 四氮杂环十二烷 - 1,4,7 - 三乙酸）螯合部分与聚氨基酸链之间连接体的能力。此外，方酸参与钆（III）离子的配位笼。对溶剂水核的1H和17O NMR弛豫过程的研究使得能够对所研究的体系进行详细表征。钆（DO3ASQ）30 - 鸟氨酸114表现出显著提高其溶液水质子弛豫率的能力，并且可被视为MRA应用的潜在造影剂。
