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双功能钆（III）螯合剂的制备策略。

Strategies for the preparation of bifunctional gadolinium(III) chelators.

作者信息

Frullano Luca, Caravan Peter

机构信息

Case Western Reserve University. 11100 Euclid Ave Cleveland, OH 44106.

出版信息

Curr Org Synth. 2011 Aug 1;8(4):535-565. doi: 10.2174/157017911796117250.

DOI:10.2174/157017911796117250
PMID:22375102
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3286626/
Abstract

The development of gadolinium chelators that can be easily and readily linked to various substrates is of primary importance for the development high relaxation efficiency and/or targeted magnetic resonance imaging (MRI) contrast agents. Over the last 25 years a large number of bifunctional chelators have been prepared. For the most part, these compounds are based on ligands that are already used in clinically approved contrast agents. More recently, new bifunctional chelators have been reported based on complexes that show a more potent relaxation effect, faster complexation kinetics and in some cases simpler synthetic procedures. This review provides an overview of the synthetic strategies used for the preparation of bifunctional chelators for MRI applications.

摘要

能够轻松且容易地与各种底物相连的钆螯合剂的开发对于高弛豫效率和/或靶向磁共振成像（MRI）造影剂的开发至关重要。在过去25年中，已制备了大量双功能螯合剂。在很大程度上，这些化合物基于已用于临床批准的造影剂中的配体。最近，已报道了基于显示出更强弛豫效果、更快络合动力学且在某些情况下合成步骤更简单的配合物的新型双功能螯合剂。本综述概述了用于制备MRI应用双功能螯合剂的合成策略。

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