Booth I W, Lander A D
Institute of Child Health, University of Birmingham, UK.
Baillieres Clin Gastroenterol. 1998 Dec;12(4):739-73. doi: 10.1016/s0950-3528(98)90006-9.
Short bowel syndrome has significant morbidity and is potentially lethal especially when intestinal loss is extensive. The pathophysiology of short bowel syndrome, its aetiology, prognosis and our understanding of the mechanisms of adaptation are reviewed. Management by a multi-disciplinary nutritional care team is advocated and should be directed to the maintenance of growth and development, the promotion of intestinal adaptation, the prevention of complications and the establishment of enteral nutrition. The choice of enteral feed, the role of drugs and the use of pro-adaptive nutrients and agents are discussed. Complications including cholestasis and catheter related sepsis are outlined with strategies to reduce them. Finally the roles of secondary surgical interventions including transplantation are discussed.
短肠综合征具有较高的发病率，尤其在肠道丢失广泛时可能危及生命。本文综述了短肠综合征的病理生理学、病因、预后以及我们对适应机制的理解。提倡由多学科营养护理团队进行管理，管理应旨在维持生长发育、促进肠道适应、预防并发症以及建立肠内营养。文中讨论了肠内喂养的选择、药物的作用以及促适应性营养素和药物的使用。概述了包括胆汁淤积和导管相关败血症在内的并发症及其减少策略。最后讨论了包括移植在内的二次手术干预的作用。
