肾结石作为炎症性肠病常见的泌尿系统表现：一项临床综述与荟萃分析
Nephrolithiasis as a common urinary system manifestation of inflammatory bowel diseases; a clinical review and meta-analysis.
作者信息
Ganji-Arjenaki Mahboube, Nasri Hamid, Rafieian-Kopaei Mahmoud
机构信息
Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
J Nephropathol. 2017 Jul;6(3):264-269. doi: 10.15171/jnp.2017.42. Epub 2017 Apr 12.
CONTEXT
The extra-intestinal manifestations of inflammatory bowel disease (IBD) are common and involve other organs or systems for example; urinary system.
EVIDENCE ACQUISITIONS
For this review, we used a variety of sources by searching through Web of Science, PubMed, EMBASE, Scopus and directory of open access journals (DOAJ).
RESULTS
Urinary complications may occur in up to 22% of patients and nephrolithiasis or renal/kidney stones have been suggested to be a common manifestation of disease in forms of uric acid, calcium phosphate or calcium oxalate. We performed a meta-analysis on five clinical trials and reported that correlation between IBD and formation of stone in renal system is positive and significant (Fix-effect model; CI: 95%, <0.001, and randomeffect model; CI: 95%, = 0.03).
CONCLUSIONS
Based on the reports of the clinical trials, calcium oxalate is more prevalent in Crohn's disease (CD) than in ulcerative colitis (UC).
背景
炎症性肠病（IBD）的肠外表现很常见，可累及其他器官或系统，例如泌尿系统。
证据获取
在本综述中，我们通过检索科学网、PubMed、EMBASE、Scopus和开放获取期刊目录（DOAJ）等多种来源。
结果
高达22%的患者可能出现泌尿系统并发症，肾结石被认为是该疾病的常见表现形式，包括尿酸、磷酸钙或草酸钙结石。我们对五项临床试验进行了荟萃分析，结果显示IBD与肾系统结石形成之间存在显著正相关（固定效应模型；95%置信区间，<0.001；随机效应模型；95%置信区间，=0.03）。
结论
基于临床试验报告，草酸钙结石在克罗恩病（CD）中比在溃疡性结肠炎（UC）中更为普遍。
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