Bush B A
University of Alabama at Birmingham, Spain Rehabilitation Center, Department of Physical Medicine and Rehabilitation 35233, USA.
Brain Inj. 1999 Feb;13(2):131-7. doi: 10.1080/026990599121791.
Depression is a significant sequela of stroke which contributes to increased morbidity and mortality in stroke survivors. Psychosocial stressors, such as major life events, pose risk factors for developing depression in non-stroke populations. This study evaluated major life events as a risk factor for developing post-stroke depression (PSD) during the first year post-stroke. One hundred and eleven patients who completed the Center for Epidemiological Studies-Depression Scale at four time periods during the first year post-stroke were assessed for PSD and asked if they had experienced a major life event in the prior 6 months (other than the stroke). The subjects completed the evaluations acutely (7-10 days), and at 3, 6, and 12 months post-stroke. At 6 months post-stroke patients were significantly more likely to be depressed if they had a major life event in the prior 6 months (other than the stroke) than if they had not, chi 2 (df = 1) = 4.83, p < 0.028, relative risk = 2.31, 95% confidence interval 1.15-4.62. Life events pose significant risks for developing PSD at 6 months post-stroke. Stroke patients need to be asked about these events and treated for PSD.
抑郁症是中风的一个重要后遗症，会导致中风幸存者的发病率和死亡率上升。心理社会压力源，如重大生活事件，是非中风人群患抑郁症的风险因素。本研究评估了重大生活事件作为中风后第一年发生中风后抑郁症（PSD）的风险因素。对111名在中风后第一年的四个时间段完成流行病学研究中心抑郁量表的患者进行PSD评估，并询问他们在之前6个月（中风除外）是否经历过重大生活事件。受试者在中风后急性阶段（7 - 10天）以及3个月、6个月和12个月时完成评估。在中风后6个月时，如果患者在之前6个月（中风除外）经历过重大生活事件，那么他们患抑郁症的可能性显著高于未经历过此类事件的患者，卡方检验（自由度 = 1）= 4.83，p < 0.028，相对风险 = 2.31，95%置信区间为1.15 - 4.62。生活事件在中风后6个月时是发生PSD的重要风险因素。需要询问中风患者这些事件并对PSD进行治疗。
