Petersen C D, Robinson W A, Kurnick J E
Am J Med Sci. 1976 Sep-Oct;272(2):161-5. doi: 10.1097/00000441-197609000-00005.
Seventeen patients with lymphomatous involvement of the heart or pericardium were studied. The series includes eight patients with Hodgkin's disease and nine with non-Hodgkin's lymphoma. All 17 had radiologia evidence of pulmonary, or mediastinal involvement. Cardiac or pericardial disease in seven was apparently due to direct extension of other intrathoracic tumor masses. Cardiac involvement was usually a late manifestation of lymphoma with median onset 20 months after initial diagnosis. Fourteen patients had been treated for stage IV disease prior to the onset of cardiac lymphoma. Only seven of the 17 patients with cardiac involvement were diagnosed antemortem. Four of them are alive without evidence of disease 8 to 68 months after diagnosis and treatment. Because cardiac lymphomas may respond to therapy with prolonged survival, it is imperative that clinicians suspect cardiac or pericardial involvement in lymphoma patients who have radiographic evidence of intrathoracic lesions (especially adjacent to cardiac borders), unexplained tachyarrhythmia or conduction disturbance, evidence of outflow obstruction, or signs and symptoms suggesting pericardial effusion or tamponade.
对17例心脏或心包受淋巴瘤累及的患者进行了研究。该系列包括8例霍奇金病患者和9例非霍奇金淋巴瘤患者。所有17例患者均有肺部或纵隔受累的放射学证据。7例患者的心脏或心包疾病显然是由于其他胸内肿瘤肿块的直接蔓延所致。心脏受累通常是淋巴瘤的晚期表现，中位发病时间为初次诊断后20个月。14例患者在心脏淋巴瘤发病前已接受IV期疾病的治疗。17例心脏受累患者中只有7例在生前被诊断出来。其中4例在诊断和治疗后8至68个月存活且无疾病证据。由于心脏淋巴瘤可能对治疗有反应并能延长生存期，因此临床医生必须怀疑那些有胸内病变（尤其是靠近心脏边界）的放射学证据、无法解释的快速性心律失常或传导障碍、流出道梗阻证据或提示心包积液或心包填塞的体征和症状的淋巴瘤患者存在心脏或心包受累。
