心脏淋巴瘤的临床特征：37例分析
Clinical features of cardiac lymphoma: an analysis of 37 cases.
作者信息
Zhao Yu, Huang Sai, Ma Chao, Zhu Haiyan, Bo Jian
机构信息
Department of Hematology, First Medical Center, 104607Chinese PLA General Hospital, Beijing, China.
出版信息
J Int Med Res. 2021 Mar;49(3):300060521999558. doi: 10.1177/0300060521999558.
OBJECTIVE
To summarize the clinical and pathological features of patients with cardiac lymphoma.
METHODS
The general conditions, clinical features, pathological types, and prognostic indices of 37 patients with cardiac lymphoma treated in our hospital were analyzed.
RESULTS
Among the 37 patients, only one had primary cardiac lymphoma, and the other 36 patients had secondary cardiac lymphoma. The cardiac manifestations were mainly chest tightness, shortness of breath, increased heart rates, and electrocardiographic abnormality caused by pericardial effusion, but myocardial enzyme levels were normal in all patients. Only three patients displayed solid heart-occupying manifestations. These lesions were mainly located in the right atrium, and the masses were all larger than 5 cm. The pathological type was diffuse large B cell lymphoma that did not arise from the germinal center in all three patients.
CONCLUSIONS
Cardiac lymphoma was mostly secondary, and pericardial effusion was the primary objective sign. Moreover, cardiac lymphoma was characterized by a high international prognostic index, late stage, and high rates of T and NK cell lymphoma. Most cases were accompanied by serous cavity effusion, extranodal involvement of important organs, elevated lactate dehydrogenase levels, hypoalbuminemia, and normal myocardial enzyme levels.
目的
总结心脏淋巴瘤患者的临床及病理特征。
方法
分析我院收治的37例心脏淋巴瘤患者的一般情况、临床特征、病理类型及预后指标。
结果
37例患者中，仅1例为原发性心脏淋巴瘤，其余36例为继发性心脏淋巴瘤。心脏表现主要为胸闷、气短、心率增快以及心包积液导致的心电图异常，但所有患者心肌酶水平均正常。仅3例患者表现为实性心脏占位。这些病变主要位于右心房，肿块均大于5 cm。3例患者的病理类型均为非生发中心来源的弥漫大B细胞淋巴瘤。
结论
心脏淋巴瘤多为继发性，心包积液是主要客观体征。此外，心脏淋巴瘤具有国际预后指数高、分期晚以及T和NK细胞淋巴瘤发生率高的特点。多数病例伴有浆膜腔积液、重要器官结外受累、乳酸脱氢酶水平升高、低蛋白血症以及心肌酶水平正常。
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