Andino R, Böddeker N, Silvera D, Gamarnik A V
Dept of Microbiology and Immunology, University of California, San Francisco 94143-0414, USA.
Trends Microbiol. 1999 Feb;7(2):76-82. doi: 10.1016/s0966-842x(98)01446-2.
Viruses replicate in a restricted number of hosts and tissues. In addition to viral receptors, several intracellular factors can be involved in determining tissue tropism. Many proteins have recently been implicated in picornavirus translation and RNA replication. Although the functional role of these proteins has not been established in vivo, it is possible that they determine cell-type tropism and the pathogenic outcome of the infection.
病毒在有限数量的宿主和组织中复制。除了病毒受体外，一些细胞内因子也可能参与决定组织嗜性。最近，许多蛋白质与小核糖核酸病毒的翻译和RNA复制有关。尽管这些蛋白质在体内的功能作用尚未确定，但它们有可能决定细胞类型嗜性和感染的致病结果。
