Intracellular determinants of picornavirus replication.

Viruses replicate in a restricted number of hosts and tissues. In addition to viral receptors, several intracellular factors can be involved in determining tissue tropism. Many proteins have recently been implicated in picornavirus translation and RNA replication. Although the functional role of these proteins has not been established in vivo, it is possible that they determine cell-type tropism and the pathogenic outcome of the infection.