Miyazato H, Skinner R D, Garcia-Rill E
Department of Anatomy, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR 72205, USA.
Brain Res. 1999 Mar 20;822(1-2):60-71. doi: 10.1016/s0006-8993(99)01074-4.
The human P1/P50 midlatency auditory evoked potential and the startle response (SR) have been used as measures of sensory and sensorimotor gating, respectively. In the present study, both prepulse and paired stimulus paradigms were used in order to investigate the relationship between sensory gating mechanisms of the P13 potential, the putative rodent equivalent of the P1 potential, and those of the SR. In addition, these were compared to the properties of the N40 potential, another measure of sensory gating. Simultaneous recordings from the vertex (P13 potential and N40 potential) and neck musculature (SR) showed that (1) in a prepulse paradigm, increasing the intensity of the prepulse or decreasing the interstimulus interval resulted in increased inhibition of the P13 potential, N40 potential (to a lesser degree) and the SR (to a greater degree), (2) when using a low signal-to-noise ratio between the prepulse intensity and the background level, prepulse inhibition of the SR was reduced or absent while that of the P13 potential was present, (3) the amplitude of the 'prepulse evoked' P13 potential was significantly correlated with prepulse inhibition of the P13 potential, the N40 potential and the SR, (4) in a paired identical stimulus paradigm, decreasing the interstimulus interval resulted in increased habituation of the P13 potential, N40 potential (to a lesser degree) and the SR, and (5) increasing the intensity of the paired stimulation resulted in increased habituation of the P13 potential and the N40 potential (to a lesser degree), but not of the SR. These results demonstrate the presence of prepulse inhibition of the P13 potential, the N40 potential and the SR in a parallel manner, but show certain specific differences in their responses to parametric changes.
人类P1/P50中潜伏期听觉诱发电位和惊跳反应（SR）分别被用作感觉门控和感觉运动门控的测量指标。在本研究中，采用了预脉冲和配对刺激范式，以研究P13电位（推测为啮齿动物P1电位的等效物）的感觉门控机制与SR的感觉门控机制之间的关系。此外，还将这些与另一种感觉门控测量指标N40电位的特性进行了比较。从头顶（P13电位和N40电位）和颈部肌肉组织（SR）同时记录的结果表明：（1）在预脉冲范式中，增加预脉冲强度或缩短刺激间隔会导致对P13电位、N40电位（程度较轻）和SR（程度较重）的抑制增加；（2）当预脉冲强度与背景水平之间的信噪比很低时，SR的预脉冲抑制减弱或不存在，而P13电位的预脉冲抑制仍然存在；（3）“预脉冲诱发”的P13电位幅度与P13电位、N40电位和SR的预脉冲抑制显著相关；（4）在配对相同刺激范式中，缩短刺激间隔会导致P13电位、N40电位（程度较轻）和SR的习惯化增加；（5）增加配对刺激的强度会导致P13电位和N40电位（程度较轻）的习惯化增加，但不会导致SR的习惯化增加。这些结果表明，P13电位、N40电位和SR以平行方式存在预脉冲抑制，但在对参数变化的反应中表现出某些特定差异。
