Homma Yuko, Homma Yutaka, Teneud Luis, Skinner Robert D, Dornhoffer John, Williams D Keith, Garcia-Rill Edgar
Department of Anatomy and Neurobiology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
J Vestib Res. 2002;12(2-3):117-25.
The P13 mid-latency auditory evoked potential in Rat is a sleep state-dependent response thought to be equivalent to the human P50 potential, a measure of the output of the reticular activating system. The amplitude of these potentials can be considered a measure of level of arousal, while, using a paired stimulus paradigm, the degree of habituation of the responses also can be assessed. Different durations of rotation were found to reduce the amplitude of the P13 potential, which recovered in a duration-dependent manner. Different durations of rotation led to decreases in habituation of the P13 potential again in a duration-dependent manner. These results suggest that rotation may affect the level of arousal as well as habituation to repetitive sensory inputs. Such effects could be interpreted to imply the presence, following rotation of sufficient duration, of a deficit in sensory gating, or distractibility, and are relevant for the study of the effects of space motion sickness.
大鼠的P13中潜伏期听觉诱发电位是一种睡眠状态依赖性反应，被认为等同于人类的P50电位，是网状激活系统输出的一种测量指标。这些电位的振幅可被视为觉醒水平的一种测量指标，同时，使用配对刺激范式，也可以评估反应的习惯化程度。发现不同的旋转持续时间会降低P13电位的振幅，其会以持续时间依赖性方式恢复。不同的旋转持续时间又会以持续时间依赖性方式导致P13电位习惯化程度降低。这些结果表明，旋转可能会影响觉醒水平以及对重复性感觉输入的习惯化。这些效应可以解释为意味着在足够长的旋转持续时间后，存在感觉门控缺陷或注意力分散，并且与太空晕动病的影响研究相关。
