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使用动脉T型移植物治疗双支冠状动脉疾病的新型微创手术技术:实验研究

New minimally invasive surgical technique using arterial T-grafts for treatment of double-vessel coronary artery disease: experimental study.

作者信息

Gulielmos V, Wagner F M, Behr F, Dangel M, Schueler S

机构信息

Cardiovascular Institute, University of Dresden, Fetscherstrasse 76, D-01307 Dresden, Germany.

出版信息

World J Surg. 1999 May;23(5):476-9. doi: 10.1007/pl00012334.

DOI:10.1007/pl00012334
PMID:10085396
Abstract

Minimally invasive surgery has been used successfully in patients with single-vessel coronary artery disease (CAD), but there are no clinical reports of surgical techniques for the treatment of multivessel disease in this field using both internal mammary arteries (IMAs). Therefore a canine model has been established to demonstrate the feasibility of a minimally invasive surgical treatment of coronary artery double-vessel disease using both IMAs. Ten mongrel dogs underwent bilateral thoracoscopic preparation of both internal mammary arteries through small left lateral chest ports. Using the Port Access endovascular cardiopulmonary bypass system the right IMA (RIMA) was anastomosed as a free graft end-to-side to the left IMA (LIMA) as a T-graft. After induction of cardioplegic arrest the RIMA was anastomosed to the circumflex artery and the LIMA to the left anterior descending artery. All animals were weaned from cardiopulmonary bypass without inotropic support. The electrocardiogram showed sinus rhythm with no signs of ischemia. Intraoperative coronary angiography demonstrated patency of all anastomoses. The minimally invasive surgical treatment of double-vessel CAD using arterial T-grafts of both IMAs is thus feasible. Surgical trauma can be further reduced by harvesting the RIMA transmediastinally through the left lateral chest.

摘要

微创手术已成功应用于单支冠状动脉疾病(CAD)患者,但尚无关于该领域使用双侧乳内动脉(IMA)治疗多支血管疾病手术技术的临床报告。因此,已建立犬模型以证明使用双侧IMA进行冠状动脉双支血管疾病微创手术治疗的可行性。十只杂种犬通过左侧小胸部切口接受双侧胸腔镜下双侧乳内动脉制备。使用端口接入式体外循环系统,将右侧IMA(RIMA)作为游离移植物端侧吻合至左侧IMA(LIMA)作为T形移植物。诱导心脏停搏后,将RIMA吻合至回旋支动脉,将LIMA吻合至左前降支动脉。所有动物均在无正性肌力支持的情况下脱离体外循环。心电图显示窦性心律,无缺血迹象。术中冠状动脉造影显示所有吻合口通畅。因此,使用双侧IMA的动脉T形移植物对双支血管CAD进行微创手术治疗是可行的。通过经纵隔从左侧胸部采集RIMA可进一步减少手术创伤。