Ackermann-Schopf C M
Arch Dermatol Res (1975). 1976 Dec 15;257(2):149-56. doi: 10.1007/BF00558088.
Circulating antibodies directed against cytoplasmic antigens of basal cells of normal human epidermis have been reported in association with various skin diseases. Since they have been found in patients with malignant melanoma it was proposed to investigate whether these antibodies are associated with other epidermal tumors such as basal or squamous cell carcinoma. With indirect immunofluorescence it was shown that sera from patients with basal (20%) and squamous cell carcinoma (16%) contained these antibodies. They could be demonstrated by cytoplasmic fluorescence of the basal epidermal cell layer. These antibodies occured almost as frequent as in malignant melanoma sera. However they do not seem to be tumorassociated as they were found in sera from patients with various benign dermatoses, with tumors of extraepidermal origin and even sporadically in sera from natural antibodies which were identified by cytoplasmic fluorescence of the outer epidermal cells, suggesting two antigenically different epidermal cell populations.
据报道，针对正常人表皮基底细胞胞质抗原的循环抗体与多种皮肤病有关。由于在恶性黑色素瘤患者中发现了这些抗体，因此有人提议研究这些抗体是否与其他表皮肿瘤有关，如基底细胞癌或鳞状细胞癌。通过间接免疫荧光法显示，基底细胞癌（20%）和鳞状细胞癌（16%）患者的血清中含有这些抗体。它们可以通过基底表皮细胞层的胞质荧光来证实。这些抗体出现的频率几乎与恶性黑色素瘤血清中的频率相同。然而，它们似乎与肿瘤无关，因为在各种良性皮肤病患者的血清中、表皮外起源的肿瘤患者的血清中甚至偶尔在天然抗体患者的血清中都发现了这些抗体，这些天然抗体通过表皮外层细胞的胞质荧光得以鉴定，这表明存在两种抗原性不同的表皮细胞群体。
