恶性黑色素瘤患者体内的循环抗体。

Circulating antibodies in malignant melanoma patients.

作者信息

Betterle C, Peserico A, Bersani G, Ninfo V, Del Prete G F, Stefani R, Nitti D

出版信息

Dermatologica. 1979;159(1):24-9. doi: 10.1159/000250557.

Abstract

Sera from 46 patients with malignant melanoma (MM) in different clinical stages and from 25 healthy blood donors were studied by an indirect conventional immunofluorescent technique (IIT) and by an immunofluorescent complement-fixation test (ICFT). No specific and reliable serological reactivity could be demonstrated against autologous and homologous MM and other nonmalignant pigmented tissues. An increased incidence of diffused antinuclear (ANA; 41%) and cytoplasmic epidermal cell autoantibodies (A-CYT; 71%) was observed in the patients by IIT. Statistical evaluation of the results gave significant values in the chi 2 test in patients for ANA (chi 2 = 5.2061; p less than 0.05) and for A-CYT (chi 2 = 8.9176; p less than 0.01) versus age-matched controls. Thyroid microsomal, gastric parietal cell, smooth muscle and mitochondria autoantibodies were, respectively, detected in 4.3, 4.3, 4.3 and 0% of patients' sera.

摘要

采用间接常规免疫荧光技术（IIT）和免疫荧光补体结合试验（ICFT），对46例处于不同临床阶段的恶性黑色素瘤（MM）患者以及25名健康献血者的血清进行了研究。未发现针对自体和同源MM以及其他非恶性色素沉着组织的特异性和可靠的血清学反应。通过IIT观察到患者中弥漫性抗核抗体（ANA；41%）和细胞质表皮细胞自身抗体（A-CYT；71%）的发生率增加。与年龄匹配的对照组相比，对结果进行统计学评估，患者的ANA（χ2 = 5.2061；p < 0.05）和A-CYT（χ2 = 8.9176；p < 0.01）在卡方检验中具有显著值。分别在4.3%、4.3%、4.3%和0%的患者血清中检测到甲状腺微粒体、胃壁细胞、平滑肌和线粒体自身抗体。