唾液乳糖对人抗-Gd冷凝集素的抑制作用。
Inhibition of human anti-Gd cold agglutinins by sialyllactose.
作者信息
Roelcke D, Brossmer R, Riesen W
出版信息
Scand J Immunol. 1978;8(3):179-85. doi: 10.1111/j.1365-3083.1978.tb00508.x.
Two examples of IgM kappa-monotopic cold agglutinins occurring in patients with non-Hodgkin lymphomas, reacted with erythrocyte autoantigens, which were protease-resistant but were inactivated by neuraminidase. The cold agglutinins were inhibited by the trisaccharide sialyllactose [NeuNAc(alpha,2 leads to 3) Gal (beta, 1 leads to 4)Glc], which is not related to oligosaccharides known to inhibit anti-I/-i cold agglutinins, Anti-Pr cold agglutinins are not inhibited by sialyllactose, although N-acetylneuraminic acid (NeuNAc) is an essential component not only of Gd but also of Pr determinants. Gd determinants are not bound to erythrocyte membrane glycoproteins, but are apparently bound to membrane glycolipids (gangliosides).
在非霍奇金淋巴瘤患者中出现的两种IgM κ单特异性冷凝集素与红细胞自身抗原发生反应，这些抗原对蛋白酶具有抗性，但可被神经氨酸酶灭活。这些冷凝集素被三糖唾液酸乳糖[NeuNAc(α,2→3)Gal(β,1→4)Glc]抑制，该三糖与已知抑制抗-I/-i冷凝集素的寡糖无关。抗-Pr冷凝集素不被唾液酸乳糖抑制，尽管N-乙酰神经氨酸（NeuNAc）不仅是Gd而且是Pr决定簇的必需成分。Gd决定簇不与红细胞膜糖蛋白结合，但显然与膜糖脂（神经节苷脂）结合。
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