Baldwin R L, Rose G D
Dept of Biochemistry, Beckman Center, Stanford University Medical Center School of Medicine, CA 94305-5307, USA.
Trends Biochem Sci. 1999 Jan;24(1):26-33. doi: 10.1016/s0968-0004(98)01346-2.
The folding reactions of some small proteins show clear evidence of a hierarchic process, whereas others, lacking detectable intermediates, do not. Nevertheless, we argue that both classes fold hierarchically and that folding begins locally. If this is the case, then the secondary structure of a protein is determined largely by local sequence information. Experimental data and theoretical considerations support this argument. Part I of this article reviews the relationship between secondary structures in proteins and their counterparts in peptides.
一些小蛋白质的折叠反应显示出明显的层次化过程的证据，而其他一些缺乏可检测中间体的蛋白质则不然。然而，我们认为这两类蛋白质都是层次化折叠的，并且折叠从局部开始。如果是这样的话，那么蛋白质的二级结构在很大程度上由局部序列信息决定。实验数据和理论思考支持这一观点。本文的第一部分回顾了蛋白质中的二级结构与其在肽中的对应结构之间的关系。
