WNT 靶点。抑制与激活。

WNT targets. Repression and activation.

作者信息

Nusse R

机构信息

Howard Hughes Medical Institute, Stanford University, CA 94305, USA.

出版信息

Trends Genet. 1999 Jan;15(1):1-3. doi: 10.1016/s0168-9525(98)01634-5.

DOI:10.1016/s0168-9525(98)01634-5

PMID:10087922

Abstract

Several puzzling observations made previously suggested that target genes that are activated by WNT signaling during development were actively repressed in the absence of the signal. Recent work sheds light on how this switch between repression and activation is regulated.

摘要

先前的一些令人困惑的观察结果表明，在发育过程中被WNT信号激活的靶基因，在没有该信号时会被积极抑制。最近的研究揭示了这种抑制与激活之间的转换是如何被调控的。