氯贝丁酯治疗对内源性高甘油三酯血症中精氨酸诱导的胰岛素分泌的影响。

Effects of clofibrate treatment on arginine-induced insulin secretion in endogenous hypertriglyceridemia.

作者信息

Fedele D, Tiengo A, Muggeo M, Nosadini R, Crepaldi G

出版信息

Atherosclerosis. 1976 Nov-Dec;25(2-3):191-8. doi: 10.1016/0021-9150(76)90025-3.

Abstract

Arginine-induced insulin secretion was evaluated in 13 patients with endogenous hypertriglyceridemia (Fredrickson's Type IV) before and after a two-month period of Clofibrate therapy. Clofibrate reduced triglyceride, cholesterol and FFA levels by 68, 28 and 15% respectively and provoked a significant reduction in arginine-induced insulin secretion without modifying glucose response. Arginine-induced insulin secretion was also studied in 11 normal subjects during saline and intralipid infusions. Glucose and insulin basal values, and glucose and insulin response to arginine infusion were not influenced by Intralipid infusion in these controls. These results confirm that clofibrate reduces insulin secretion thereby contributing to decreased serum triglyceride levels.

摘要

在13例内源性高甘油三酯血症（弗雷德里克森IV型）患者中，在进行为期两个月的氯贝丁酯治疗前后，评估精氨酸诱导的胰岛素分泌情况。氯贝丁酯分别使甘油三酯、胆固醇和游离脂肪酸水平降低了68%、28%和15%，并在不改变葡萄糖反应的情况下，使精氨酸诱导的胰岛素分泌显著减少。还在11名正常受试者中，在输注生理盐水和脂肪乳剂期间研究了精氨酸诱导的胰岛素分泌。在这些对照中，葡萄糖和胰岛素基础值以及对精氨酸输注的葡萄糖和胰岛素反应不受脂肪乳剂输注的影响。这些结果证实，氯贝丁酯可减少胰岛素分泌，从而有助于降低血清甘油三酯水平。