Schwandt P, Weisweiler P, Neureuther G, Wilkening J
MMW Munch Med Wochenschr. 1976 Mar 19;118(12):351-4.
In 22 patients with endogenous hypertriglyceridemia, oral and intravenous glucose tolerance showed significant improvement under clofibrate treatment which was in no way correlated to the fall in triglycerides. Basal and stimulated insulin, cholesterol and fasting blood sugar did not change, body weight remained constant and was not correlated to the degree of hypertriglyceridemia. On the other hand a positive correlation between body weight and insulin concentrations was found. Improvement of glucose tolerance independently of body weight and insulin may be due to a direct effect of clofibrate on glucose metabolism without any correlation to its triglyceride-lowering.
在22例内源性高甘油三酯血症患者中，口服和静脉葡萄糖耐量在氯贝丁酯治疗下有显著改善，这与甘油三酯的下降毫无关联。基础和刺激状态下的胰岛素、胆固醇及空腹血糖均未改变，体重保持恒定，且与高甘油三酯血症程度无关。另一方面，发现体重与胰岛素浓度之间呈正相关。葡萄糖耐量的改善独立于体重和胰岛素，可能是由于氯贝丁酯对葡萄糖代谢有直接作用，与其降低甘油三酯的作用无关。
