大鼠肉瘤模型支持转移扩散的“土壤种子”和“机械”理论。
Rat sarcoma model supports both "soil seed" and "mechanical" theories of metastatic spread.
作者信息
Proctor J W
出版信息
Br J Cancer. 1976 Dec;34(6):651-4. doi: 10.1038/bjc.1976.227.
Abstract
Following injection into the portal venous or vena caval systems, tumour cells are held up almost exclusively in the liver or lung respectively, and subsequent outgrowth of tumour only occurs in these organs. Following systemic arterial injection, cells are distributed, and subsequently grow, in a variety of organs. However, the adrenal gland supports tumour growth from much fewer cells than the lung, and this is partly due to the fact the rate of tumour cell loss in the initial 48 h is very high in the latter compared to the former organ.
摘要
在将肿瘤细胞注入门静脉或腔静脉系统后，肿瘤细胞几乎仅分别滞留在肝脏或肺中，随后肿瘤仅在这些器官中生长。在进行全身动脉注射后，细胞会分布在各种器官中并随后生长。然而，肾上腺支持肿瘤生长所需的细胞比肺要少得多，部分原因是与肾上腺相比，在最初48小时内肺中肿瘤细胞的损失率非常高。
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2
3
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J Natl Cancer Inst. 1970 Oct;45(4):773-82.
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