大鼠肉瘤模型支持转移扩散的“土壤种子”和“机械”理论。
Rat sarcoma model supports both "soil seed" and "mechanical" theories of metastatic spread.
作者信息
Proctor J W
出版信息
Br J Cancer. 1976 Dec;34(6):651-4. doi: 10.1038/bjc.1976.227.
Abstract
Following injection into the portal venous or vena caval systems, tumour cells are held up almost exclusively in the liver or lung respectively, and subsequent outgrowth of tumour only occurs in these organs. Following systemic arterial injection, cells are distributed, and subsequently grow, in a variety of organs. However, the adrenal gland supports tumour growth from much fewer cells than the lung, and this is partly due to the fact the rate of tumour cell loss in the initial 48 h is very high in the latter compared to the former organ.
摘要
在将肿瘤细胞注入门静脉或腔静脉系统后，肿瘤细胞几乎仅分别滞留在肝脏或肺中，随后肿瘤仅在这些器官中生长。在进行全身动脉注射后，细胞会分布在各种器官中并随后生长。然而，肾上腺支持肿瘤生长所需的细胞比肺要少得多，部分原因是与肾上腺相比，在最初48小时内肺中肿瘤细胞的损失率非常高。
相似文献
1
Rat sarcoma model supports both "soil seed" and "mechanical" theories of metastatic spread.大鼠肉瘤模型支持转移扩散的“土壤种子”和“机械”理论。
Br J Cancer. 1976 Dec;34(6):651-4. doi: 10.1038/bjc.1976.227.
2
Mechanisms of organ selective tumour growth by bloodborne cancer cells.血源癌细胞器官选择性肿瘤生长的机制。
Br J Cancer. 1988 Jan;57(1):19-31. doi: 10.1038/bjc.1988.3.
3
Influence of vascular permeability on blood-borne metastasis.血管通透性对血行转移的影响。
Gan. 1973 Feb;64(1):1-5.
4
Organ preferences in metastatic colony formation by spontaneous mammary carcinomas after intra-arterial inoculation.动脉内接种后自发性乳腺癌转移瘤形成中的器官偏好性
Invasion Metastasis. 1983;3(4):208-20.
5
6
The effect of Warfarin and factor VII on tissue procoagulant activity and pulmonary seeding.华法林和凝血因子VII对组织促凝活性及肺播散的影响。
Br J Cancer. 1992 Mar;65(3):329-34. doi: 10.1038/bjc.1992.67.
7
Cell culture from a rat brain tumor induced by intracerebral inoculation with murine sarcoma virus.通过脑内接种鼠肉瘤病毒诱导的大鼠脑肿瘤的细胞培养。
J Natl Cancer Inst. 1974 Aug;53(2):431-47. doi: 10.1093/jnci/53.2.431.
8
A preliminary investigation into the role of immunity in modifying the blood- borne spread of chemically induced rat sarcomas.关于免疫在改变化学诱导大鼠肉瘤血行扩散中作用的初步研究。
J Natl Cancer Inst. 1974 Dec;53(6):1671-6.
9
Malignant cells in the peripheral blood and their significance in metastasis formation.
Acta Cytol. 1969 Jul;13(7):395-8.
10
Pattern of spread of bloodborne tumour.血源性肿瘤的扩散模式。
Br J Surg. 1986 Oct;73(10):829-34. doi: 10.1002/bjs.1800731024.
引用本文的文献
1
Biology of breast cancer brain metastases and novel therapies targeting the blood brain barrier: an updated review.乳腺癌脑转移的生物学特性和血脑屏障靶向新型治疗策略：最新综述。
Med Oncol. 2023 May 18;40(6):181. doi: 10.1007/s12032-023-02047-0.
2
Organ vascularity and metastatic frequency.器官血管分布与转移频率。
Am J Pathol. 1980 Oct;101(1):101-13.
3
Difference in proliferation-kinetics between tumor cells arrested in the brain and liver.
Experientia. 1982 Oct 15;38(10):1236-7. doi: 10.1007/BF01959761.
4
Clonal variation in the arrest, survival and growth of RIF-1 mouse sarcoma cells in the lungs of C3H mice.RIF-1小鼠肉瘤细胞在C3H小鼠肺部的停滞、存活及生长的克隆变异
Br J Cancer. 1983 Jun;47(6):833-40. doi: 10.1038/bjc.1983.138.
5
'Seed and soil' revisited: mechanisms of site-specific metastasis.重温“种子与土壤”：器官特异性转移的机制
Cancer Metastasis Rev. 1982;1(1):5-16. doi: 10.1007/BF00049477.
6
Brain meninges tumor formation by in vivo-selected metastatic B16 melanoma variants in mice.小鼠体内选择的转移性B16黑色素瘤变体形成脑脑膜肿瘤
Clin Exp Metastasis. 1983 Jul-Sep;1(3):247-59. doi: 10.1007/BF00736408.
7
Selection of liver-colonizing tumor cells from a murine fibrosarcoma induced by methylcholanthrene.从甲基胆蒽诱导的小鼠纤维肉瘤中筛选肝转移性肿瘤细胞。
J Cancer Res Clin Oncol. 1984;108(3):274-80. doi: 10.1007/BF00390457.
8
Analysis of the lodgement and extravasation of tumor cells in experimental models of hematogenous metastasis.血行转移实验模型中肿瘤细胞着床与外渗的分析
Cancer Metastasis Rev. 1986;5(2):77-94. doi: 10.1007/BF00046424.
9
Mechanism of liver-specific metastatic tumor spread in a murine tumor model.小鼠肿瘤模型中肝脏特异性转移性肿瘤扩散的机制
J Cancer Res Clin Oncol. 1988;114(1):47-58. doi: 10.1007/BF00390485.
10
Mechanisms of organ selective tumour growth by bloodborne cancer cells.血源癌细胞器官选择性肿瘤生长的机制。
Br J Cancer. 1988 Jan;57(1):19-31. doi: 10.1038/bjc.1988.3.
本文引用的文献
1
The organ selectivity of experimentally induced metastases in rats.大鼠实验性诱导转移的器官选择性
Cancer. 1952 May;5(3):606-12. doi: 10.1002/1097-0142(195205)5:3<606::aid-cncr2820050324>3.0.co;2-u.
2
3
Mechanisms responsible for the origin and distribution of blood-borne tumor metastases: a review.血行性肿瘤转移的起源和分布机制：综述
Cancer Res. 1953 Jun;13(6):397-404.
4
Metastasis: quantitative analysis of distribution and fate of tumor emboli labeled with 125 I-5-iodo-2'-deoxyuridine.转移：对用¹²⁵I - 5 - 碘 - 2'-脱氧尿苷标记的肿瘤栓子的分布及转归进行定量分析。
J Natl Cancer Inst. 1970 Oct;45(4):773-82.
5
Breast volumes in cancer of the breast.乳腺癌中的乳房体积
Br J Cancer. 1974 Mar;29(3):270-3. doi: 10.1038/bjc.1974.66.
6
The distribution and fate of blood-borne 125IUdR-labelled tumour cells in immune syngeneic rats.免疫同基因大鼠中血源性125IUdR标记肿瘤细胞的分布与转归
Int J Cancer. 1976 Aug 15;18(2):255-62. doi: 10.1002/ijc.2910180217.
Zotero 插件