Murphy P, Alexander P, Kirkham N, Fleming J, Taylor I
Br J Surg. 1986 Oct;73(10):829-34. doi: 10.1002/bjs.1800731024.
The pattern of bloodborne tumour spread has been studied experimentally in syngeneic rats. A variety of tumour types has been injected intravenously, intraportally and also intra-arterially via the left ventricle. Tumour cell arrest as a factor in the localization of metastases in the lung following intravenous injection of cells, and in the liver following intraportal injection, is emphasized. Once tumour cells have entered the arterial circulation they disseminate to almost all organs in similar proportions to the distribution of cardiac output. The dissemination and arrest of cells is not found to correlate with the later distribution of metastases. For example, certain organs (especially the adrenals) which receive only low fractions of injected cells, are always preferred sites for bloodborne metastasis. A strikingly similar pattern of 'arterial metastasis' is also seen for all the tumours used despite their very different histological and biological natures.
在同基因大鼠中对血行性肿瘤转移模式进行了实验研究。已通过静脉、门静脉以及经左心室动脉内注射了多种肿瘤类型。静脉注射细胞后肺内转移灶定位以及门静脉注射后肝内转移灶定位中，强调肿瘤细胞滞留是一个因素。一旦肿瘤细胞进入动脉循环，它们会以与心输出量分布相似的比例扩散到几乎所有器官。未发现细胞的扩散和滞留与转移灶的后期分布相关。例如，某些仅接受少量注射细胞的器官（尤其是肾上腺），始终是血行转移的首选部位。尽管所用的所有肿瘤在组织学和生物学性质上有很大差异，但仍观察到了惊人相似的“动脉转移”模式。
