Stewart A, Black A, Robins S P, Reid D M
Department of Medicine and Therapeutics, University of Aberdeen, UK.
J Rheumatol. 1999 Mar;26(3):622-6.
Osteoarthritis (OA) and osteoporosis (OP) are reported to be rare in the same patient. We examined bone mass, bone turnover, and radiological presence of OA in a group of patients with OA with previous hip fractures and age matched controls.
Bone mass was assessed by bone mineral density (BMD), using dual energy x-ray absorptiometry (DEXA) of the hip and total body, and quantitative ultrasound of the os calcis, measuring broadband ultrasound attenuation and velocity of sound. Bone turnover was assessed by measuring urinary pyridinium crosslinks and serum osteocalcin.
There were differences in bone density, the patients with OP having lower bone density, while patients with OA had similar or increased bone density compared to controls, Serum osteocalcin showed no significant differences among the 3 groups of patients. Urinary pyridinium crosslinks excretion was significantly elevated in the OA group but not in the OP group compared with controls.
Increased bone turnover was restricted to the OA group.
据报道，骨关节炎（OA）和骨质疏松症（OP）在同一患者中较为罕见。我们研究了一组既往有髋部骨折的OA患者以及年龄匹配的对照组的骨量、骨转换和OA的影像学表现。
采用双能X线吸收法（DEXA）测量髋部和全身的骨密度（BMD），并通过定量超声测量跟骨的宽带超声衰减和声速，以此评估骨量。通过测量尿吡啶交联物和血清骨钙素评估骨转换。
骨密度存在差异，OP患者的骨密度较低，而与对照组相比，OA患者的骨密度相似或有所增加。三组患者的血清骨钙素无显著差异。与对照组相比，OA组尿吡啶交联物排泄显著升高，而OP组未升高。
骨转换增加仅限于OA组。
