Jakobsson P J, Morgenstern R, Mancini J, Ford-Hutchinson A, Persson B
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Protein Sci. 1999 Mar;8(3):689-92. doi: 10.1110/ps.8.3.689.
A novel superfamily designated MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism), including members of widespread origin with diversified biological functions is defined according to enzymatic activities, sequence motifs, and structural properties. Two of the members are crucial for leukotriene biosynthesis, and three are cytoprotective exhibiting glutathione S-transferase and peroxidase activities. Expression of the most recently recognized member is strongly induced by p53, and may therefore play a role in apoptosis or cancer development. In spite of the different biological functions, all six proteins demonstrate common structural characteristics typical of membrane proteins. In addition, homologues are identified in plants, fungi, and bacteria, demonstrating this superfamily to be generally occurring.
一个新的超家族被命名为MAPEG（类花生酸和谷胱甘肽代谢中的膜相关蛋白），它根据酶活性、序列基序和结构特性来定义，其成员来源广泛，具有多种生物学功能。其中两个成员对白三烯的生物合成至关重要，另外三个具有细胞保护作用，表现出谷胱甘肽S-转移酶和过氧化物酶活性。最近发现的成员的表达受p53强烈诱导，因此可能在细胞凋亡或癌症发展中起作用。尽管具有不同的生物学功能，但所有六种蛋白质都表现出膜蛋白典型的共同结构特征。此外，在植物、真菌和细菌中也鉴定出了同源物，表明这个超家族普遍存在。
